누드마우스에서의 사람탈회상아질기질 과립에 의한 골유도
Bone induction of human particulated demineralized dentin matrix in nude mice
김현철, 무라타 마사루, 아카자와 토시유키,
소속 상세정보
김현철 ( Kim Hyoun-Chull ) - 리빙웰치과병원
무라타 마사루 ( Masaru Murata ) - 북해도대학교 보건과학대학 치과대학 구강악안면외과
아카자와 토시유키 ( Toshiyuki Akazawa ) - 북해도 공업연구소
KMID : 0362820110300010009
Abstract
Purpose: The aim of this study evaluated the osteoinductive properties of human demineralized dentin matrix (DDM) in the subcutaneous tissue in nude mice.
Materials & Method: A human demineralized dentin matrix was prepared from extracted vital 3rd molar and implanted into the subcutaneous tissue in nude mice. The demineralized dentin matrix was particulated and its size varied from 400 to 800㎛. The hard tissue inducted by 70 mg of the demineralized dentin matrix was estimated at 4weeks after implantation histomorphometrically.
Results: The demineralized dentin matrix induced bone and cartilage independently. Appositional forming of new bone was formed on the surface of demineralized dentin matrix and regular arrangement of osteoblasts were observed. Cartilage was observed between demineralized dentin matrix particles as a scaffold. Histological examination showed that the demineralized dentin matrix induced bone and cartilage, 0.9% and 0.4% in morphometric analysis, respectively. The demineralized dentin matrix occupied 74.7% in the volume of the total tissues.
Conclusion: This results showed that the human demineralized dentin matrix particles are osteoinductive insoluble matrices.
키워드
Collagen; Dentin; Human;Purpose : The aim of this study evaluated the osteoinductive properties of human demineralized dentin matrix (DDM) in the Osteoinduction
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